Let’s take fonts, for example. Debates have raged for years over whether one’s manuscript should be printed using a Courier or a Times New Roman font. Over the course of my career, I’ve written books for several major publishers, and to tell you the truth, I’ve never known a single one who cared whether you used a Courier or a Times New Roman font or some other font, as long as it was legible (warning: you really won’t do yourself any favors if you think BuxomD is appropriate for a romance or Shotgun for a western).
For my first several manuscripts, I used a Letter Gothic font, because that was the only font ball I had for my typewriter (we didn’t have personal computers then). No publisher ever sent me a rejection letter telling me I had used the wrong font. In fact, to this day, the subject of fonts has never even come up. From Letter Gothic, I moved on to Palatino; my publishers never said a word. Nor did they speak up when I eventually switched to Century Schoolbook, then finally to Times New Roman.